Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4,4’,4’’,4’’’-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine
Purity: ≥98%
Formula Markup: C24H16N4S
Formula Weight: 392.5
CAS Number: 64048-12-0
Notes: Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. GANT 58 is a Gli antagonist that inhibits Gli1-mediated transcription (EC50 = 5 μM) in a variety of cell types.{22122,22692,22693} It inhibits the hh signaling pathway downstream of Smo and the endogenous downstream inhibitor Sufu thereby affecting Gli1 nuclear accumulation.{22122} GANT 58 displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.{22692,22693}
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