GC7 (sulfate), CAS 150417-90-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (7-aminoheptyl)-guanidine, monosulfate

Purity: ≥98%

Formula Markup: C8H20N4 / H2SO4

Formula Weight: 270.35084

CAS Number: 150417-90-6

Notes: GC7 is an inhibitor of deoxyhypusine synthase (Ki = 9.7 nM), an enzyme that participates in the biosynthesis of the amino acid hypusine, which is formed post-translationally on eukaryotic initiation factor 5A (eIF5A).{63208} It inhibits the production of hypusine in CHO cells when used at a concentration of 1 µM. GC7 (20 µM) inhibits activation of eIF5A2 and enhances the cytotoxicity of doxorubicin in Huh7 and HepG2 cells.{63209} It reduces tumor growth in a Melan-a Tm5 murine melanoma model when administered at a dose of 0.9 mg/kg.{63210}

• SKU: CAY34761-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34761-25
• Package Unit: 25 mg
• Quantity Unit: STK