GDC-0575, CAS 1196541-47-5

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[4-[(3R)-3-amino-1-piperidinyl]-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl]-cyclopropanecarboxamide

Purity: ≥98%

Formula Markup: C16H20BrN5O

Formula Weight: 378.2671

CAS Number: 1196541-47-5

Notes: GDC-0575 is an inhibitor of checkpoint kinase 1 (Chk1; IC50 = 1.2 nM).{62204} It is greater than 30-fold selective for Chk1 over a panel of more than 450 wild-type and mutant kinases. GDC-0575 (500 nM) enhances apoptosis induced by cytarabine (Item No. 16069) in HL-60, KG-1, U937, and ML-1 human acute myeloid leukemia (AML) cells. It nearly completely eliminates tumor burden in AML patient-derived xenograft (PDX) mouse models when administered at a dose of 7.5 mg/kg in combination with cytarabine.

• SKU: CAY34300-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34300-10
• Package Unit: 10 mg
• Quantity Unit: STK