GDC-0941, CAS 957054-30-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine

Purity: ≥98%

Formula Markup: C23H27N7O3S2

Formula Weight: 513.6

CAS Number: 957054-30-7

Notes: The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival.{13740,17822} GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively.{24602,24604} It is much less effective against class II-IV isoforms of PI3K and against mTOR.{24602,24603} GDC-0941 inhibits the growth of certain types of cancer cells and blocks signaling through PI3K to Akt, both in cells and in vivo.{24602,24605}

• SKU: CAY11600-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11600-10
• Package Unit: 10 mg
• Quantity Unit: STK