Gefitinib, CAS 184475-35-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine

Purity: ≥98%

Formula Markup: C22H24ClFN4O3

Formula Weight: 446.9

CAS Number: 184475-35-2

Notes: Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 µM).{61750} It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 µM).{17856} Gefitinib (0.1 to 1 µM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).

• SKU: CAY13166-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13166-1
• Package Unit: 1 g
• Quantity Unit: STK