GKT136901, CAS 955272-06-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-(2-chlorophenyl)-4-methyl-5-(2-pyridinylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione

Purity: ≥95%

Formula Markup: C19H15ClN4O2

Formula Weight: 366.80086

CAS Number: 955272-06-7

Notes: GKT136901 is a dual inhibitor of NADPH oxidase 1 (NOX1) and NOX4 (Kis = 160 and 165 nM, respectively).{28982} It is selective for NOX1 and NOX4 over NOX2 and xanthine oxidase (Kis = 1,530 and >30,000 nM, respectively), as well as over a panel of 18 enzymes and ion channels at 10 µM. GKT136901 (0.1, 1, and 10 µM) scavenges peroxynitrite radicals, as well as prevents the nitration and dimerization of α-synuclein, in cell-free assays.{63043} It prevents peroxynitrite-induced cell death of differentiated LUHMES cells when used at a concentration of 10 µM.

• SKU: CAY34205-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34205-25
• Package Unit: 25 mg
• Quantity Unit: STK