Product Description: Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
Applications: COVID-19-immunoregulation
Formula: C6H14ClNO5
Citations: Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun./Int Immunopharmacol. 2024 Oct 18;143(Pt 2):113427./Microbiome. 2019 Mar 20;7(1):43. /Nature. 2024 Dec 18./Theranostics. 2021 Mar 24;11(12):5650-5674.
References: [1]Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9./[2]Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706./[3]Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84./[4]Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7.
CAS Number: 66-84-2
Molecular Weight: 215.63
Compound Purity: 98.0
Research Area: Inflammation/Immunology; Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: Autophagy;Endogenous Metabolite;HIF/HIF Prolyl-Hydroxylase;Reactive Oxygen Species
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