Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[(3a,5ß,7a)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C26H39D4NO5
Formula Weight: 453.7
CAS Number: 1201918-16-2
Notes: An internal standard for the quantification of glycochenodeoxycholic acid (GCDCA; Item No. 16942) by GC- or LC-MS. GCDCA is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid (Item No. 10011286).{57144} It reduces formation of cholic acid (Item No. 20250) in primary human hepatocytes when used at a concentration of 100 µM.{57145} GCDCA (50, 75, and 100 µM) reduces the number of LC3 puncta, a marker of autophagy, and is cytotoxic to L-02 hepatocytes.{57144} GCDCA (50 µM) induces apoptosis in isolated rat hepatocytes, an effect that can be blocked by the protein kinase C (PKC) inhibitor chelerythrine (Item No. 11314).{57146} Fecal levels of GCDCA are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}
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