Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2R)-N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide
Purity: ≥90%
Formula Markup: C20H28N4O4
Formula Weight: 388.5
CAS Number: 142880-36-2
Notes: GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs).{25222} It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with Ki values of 20 nM.{25221} GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM.{25216,25215,25118,25121} It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations.{25217,25214} It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (Ki = 2.74 μM).{25219} GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC50 = 38 nM).{25220}
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