GNE-317, CAS 1394076-92-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5-[6-(3-methoxy-3-oxetanyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-2-pyrimidinamine

Purity: ≥98%

Formula Markup: C19H22N6O3S

Formula Weight: 414.48262

CAS Number: 1394076-92-6

Notes: GNE-317 is a dual inhibitor of PI3Kα and the mammalian target of rapamycin (mTOR; apparent Kis = 2 and 9 nM, respectively).{58697} It inhibits the proliferation of PC3 prostate cancer and A172 glioblastoma cells with EC50 values of 132 and 240 nM, respectively. GNE-317 (10-40 mg/kg) reduces tumor growth in a U87MG/M glioblastoma mouse xenograft model.

• SKU: CAY27671-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27671-25
• Package Unit: 25 mg
• Quantity Unit: STK