GNE-6640, CAS 2009273-67-8

Product Description: GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2].

Applications: Cancer-Kinase/protease

Formula: C20H18N4O

References: [1]Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538./[2]Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85(4):627-639.

CAS Number: 2009273-67-8

Molecular Weight: 330.38

Compound Purity: 99.91

Research Area: Cancer

Solubility: DMSO : 5 mg/mL (ultrasonic)

Target: Deubiquitinase

• SKU: MEXHY-112937-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112937-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK