Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-(2-hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide
Purity: ≥95%
Formula Markup: C20H17F3N4O3
Formula Weight: 418.4
CAS Number: 778277-15-9
Notes: GNF-5 is an allosteric inhibitor of Bcr-Abl (IC50 = 0.121 µM) and a derivative of GNF-2 (Item No. 16253).{61146} It also inhibits the Bcr-Abl mutants Bcr-AblG250E, Bcr-AblE255V, and Bcr-AblM351T (IC50s = 4.52, 0.38, and 0.93 µM, respectively).{30754} GNF-5 inhibits the growth of Ba/F3 cells (IC50 = 0.145 µM).{61146} It reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, when used at a concentration of 10 µM via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion.{45828} GNF-5 (75 mg/kg) increases survival in a recalcitrant mutant Bcr-AblT315I mouse bone marrow transplantation model when administered alone or in combination with nilotinib.{30754}
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