Gö 6976, CAS 136194-77-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile

Purity: ≥98%

Formula Markup: C24H18N4O

Formula Weight: 378.4

CAS Number: 136194-77-9

Notes: Gö 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively.{9057} It does not inhibit the activity of PKCδ, PKCε, or PKCζ (IC50s > 3 μM), indicating a preference for the Ca2+-dependent subtypes, PKCα and PKCβ1.{9057} Gö 6976 also inhibits the checkpoint kinases Chk1/2.{30717} It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.{30717,24026}

• SKU: CAY13310-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13310-1
• Package Unit: 1 mg
• Quantity Unit: STK