Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (6R,7S,12aS)-5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-dibenzo[a,c]cyclooctene-3,10-diol
Purity: ≥98%
Formula Markup: C22H28O6
Formula Weight: 388.45412
CAS Number: 66280-25-9
Notes: Gomisin J is a lignan that has been found in Schisandra chinensis and has diverse biological activities.{52505,52506} It inhibits HIV-1 IIIB replication in H9 T cells (EC50 = 1.5 µg/ml).{52505} Gomisin J (20 µM) decreases LPS-induced increases in nitric oxide (NO) production and p38, ERK, and JNK phosphorylation in RAW 264.7 cells.{52506} It induces relaxation of isolated, precontracted endothelium-intact rat aortic rings when used at concentrations of 3, 10, and 30 µg/ml.{52508} Gomisin J is cytotoxic to 13 cancer cell lines, including breast, colon, and cervical cancer cells, when used at a concentration of 30 µg/ml.{52507}
English
Deutsch
