GSK-3685032, CAS 2170137-61-6

Product Description: GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1].

Applications: Cancer-programmed cell death

Formula: C22H24N6OS

References: [1]Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017.

CAS Number: 2170137-61-6

Molecular Weight: 420.53

Compound Purity: 99.95

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic)

Target: DNA Methyltransferase

• SKU: MEXHY-139664-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-139664-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK