GSK-843, CAS 1601496-05-2

Product Description: GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation[1][2].

Applications: COVID-19-immunoregulation

Formula: C19H15N5S2

References: [1]Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95./[2]Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25;288(43):31268-79.

CAS Number: 1601496-05-2

Molecular Weight: 377.49

Compound Purity: 99.18

Research Area: Inflammation/Immunology

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Apoptosis;RIP kinase

• SKU: MEXHY-125402-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-125402-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK