GSK1059615, CAS 958852-01-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5Z-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione

Purity: ≥98%

Formula Markup: C18H11N3O2S

Formula Weight: 333.4

CAS Number: 958852-01-2

Notes: PI 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation. Its signaling pathway is the most commonly mutated pathway in human cancers. GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM) and the common activating mutants of p110α (E542K, E545K, and H1047R) found in cancer.{20675,20676} It prevents proliferation in BT474 tumor xenografts and reduces MAPK signaling following twice daily dosing at 25 mg/kg.{20675}

• SKU: CAY11569-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11569-10
• Package Unit: 10 mg
• Quantity Unit: STK