GSK180736A, CAS 817194-38-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide

Purity: ≥98%

Formula Markup: C19H16FN5O2

Formula Weight: 365.361243

CAS Number: 817194-38-0

Notes: GSK180736A is an inhibitor of Rho-associated kinase 1 (ROCK1; IC50 = 14 nM) and G protein-coupled receptor kinase 2 (GRK2; IC50 = 0.77 µM).{26327,42595} It is selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all) and selective for ROCK1 over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively).{26327,42595} GSK180736A increases maximum contractility in isolated mouse cardiomyocytes when used at a concentration of 1 µM.{42595}

• SKU: CAY26182-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26182-5
• Package Unit: 5 mg
• Quantity Unit: STK