GSK2981278, CAS 1474110-21-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C25H35NO5S

Formula Weight: 461.6

CAS Number: 1474110-21-8

Notes: GSK2981278 is an inverse agonist of retinoic acid receptor-related nuclear receptor γ (RORγ; IC50 = 17 nM in a transactivation assay).{63393} It is selective for RORγ over RORα.{34217} GSK2981278 inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing conditions (IC50 = 3.2 nM). Topical application of GSK2981278 (1% ointment) reduces dermal symptoms in a mouse model of psoriasis induced by imiquimod (Item No. 14956).

• SKU: CAY20974-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20974-5
• Package Unit: 5 mg
• Quantity Unit: STK