GSK4112, CAS 1216744-19-2

Product Description: GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C18H21ClN2O4S

References: [1]Grant D, et al. GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol. 2010 Oct 15;5(10):925-932./[2]Shao R, et al. REV-ERBα Agonist GSK4112 attenuates Fas-induced Acute Hepatic Damage in Mice. Int J Med Sci. 2021 Oct 25;18(16):3831-3838.

CAS Number: 1216744-19-2

Molecular Weight: 396.89

Compound Purity: 99.87

Research Area: Metabolic Disease

Solubility: DMSO : 25 mg/mL (ultrasonic)

Target: Apoptosis;REV-ERB

• SKU: MEXHY-14414-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-14414-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK