GSK467, CAS 1628332-52-4

Product Description: GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1][2].

Applications: Cancer-programmed cell death

Formula: C17H13N5O2

References: [1]Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45./[2]Fu YD, et al. Targeting histone demethylase KDM5B for cancer treatment. Eur J Med Chem. 2020 Dec 15;208:112760./[3]Guo JC, et al. KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis. J Cell Mol Med. 2021 Apr 7;25(13):5949–62.

CAS Number: 1628332-52-4

Molecular Weight: 319.32

Compound Purity: 99.55

Research Area: Cancer

Solubility: DMSO : 20.83 mg/mL (ultrasonic)

Target: Histone Demethylase

• SKU: MEXHY-116761-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-116761-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK