GSK481, CAS 1622849-58-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-3-isoxazolecarboxamide

Purity: ≥98%

Formula Markup: C21H19N3O4

Formula Weight: 377.4

CAS Number: 1622849-58-4

Notes: GSK481 is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM.{33779} It is selective for RIP1 over a panel of over 450 other kinases, including RIP3.{33778,33779} GSK481 inhibits RIP1 from human and cynomolgus monkey but is at least 100-fold less potent against non-primate RIP1.{33779}

• SKU: CAY20308-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20308-1
• Package Unit: 1 mg
• Quantity Unit: STK