GSK484 (hydrochloride), CAS 1652591-81-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: [(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone, monohydrochloride

Purity: ≥95%

Formula Markup: C27H31N5O3 / HCl

Formula Weight: 510.0

CAS Number: 1652591-81-5

Notes: GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme.{28376} It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.{28376} It exhibits favorable pharmacokinetic profiles in mouse and rat. See the Structural Genomics Consortium (SGC) website for more information.

• SKU: CAY17488-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17488-5
• Package Unit: 5 mg
• Quantity Unit: STK