GSK583, CAS 1346547-00-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine

Purity: ≥98%

Formula Markup: C20H19FN4O2S

Formula Weight: 398.5

CAS Number: 1346547-00-9

Notes: GSK583 is a selective inhibitor of RIP-like interacting CLARP kinase (RICK also known as RIP2 kinase; IC50 = 5 nM).{31440} RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines. In an ex vivo human translational model using intestinal mucosal tissue from inflammatory bowel disease patients, GSK583 inhibited both TNF-α and IL-6 production with an IC50 value of 200 nM.{31440}

• SKU: CAY19739-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19739-50
• Package Unit: 50 mg
• Quantity Unit: STK