GSK805, CAS 1426802-50-7

Product Description: GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity[1].

Applications: COVID-19-immunoregulation

Formula: C23H18Cl2F3NO4S

References: [1]Wang Y, et al. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors. ACS Med Chem Lett. 2015 May 26;6(7):787-792./[2]Xiao S, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40(4):477-89.

CAS Number: 1426802-50-7

Molecular Weight: 532.36

Compound Purity: 98.01

Research Area: Inflammation/Immunology

Solubility: DMSO : ≥ 100 mg/mL

Target: ROR

• SKU: MEXHY-12776-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12776-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK