GSK923295, CAS 1088965-37-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)-benzamide

Purity: ≥98%

Formula Markup: C32H38ClN5O4

Formula Weight: 592.1

CAS Number: 1088965-37-0

Notes: GSK923295 is a potent inhibitor of centromere-associated protein E (CENP-E; Ki = 3.2 nM), a kinesin motor protein involved in mitotic checkpoint signaling.{31966,31965} GSK923295 causes mitotic cell cycle delay, leading to apoptosis in various cancer cell lines.{31966} It induces apoptosis in cancer cells in mice bearing xenografts of COLO 205 cells.{31966,31965} GSK923295 can be used with AZ3146, an inhibitor of the spindle checkpoint kinase Mps1, to generate aneuploidy in cells.{31964}

• SKU: CAY18389-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 18389-5
• Package Unit: 5 mg
• Quantity Unit: STK