Target Synonym: KRAS;KRAS2;RASK2;GTPase Kras;K-Ras 2;Ki-Ras;c-K-ras;c-Ki-ras;GTPase Kras
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: KRAS,also called p21,is a member of the Ras superfamily of proteins. It is located on human chromosome 12,and contains four coding exons and a 5' non-coding exon (PMID: 12778136). KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate (GTP/GDP)-binding protein and is widely expressed in most human cells. Like other members of the Ras family,the KRAS protein is a GTPase,and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687). KRAS mutations have been found in various malignancies,including lung adenocarcinoma,mucinous adenoma,ductal carcinoma of the pancreas and colorectal carcinoma.
Buffer: PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
Immunogen: Recombinant Human KRAS protein expressed by E.coli.
Dilution: WB 1:1000-1:2000
Calculated MW: 21 kDa
Observed MW: 21 kDa
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