Product Description: Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI)[1][2][3][4][5].
Applications: COVID-19-immunoregulation
Formula: C10H13N5Na2O11P2
References: [1]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097./[2]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. /[3]Ciruela F. Guanosine behind the scene. J Neurochem. 2013 Aug;126(4):425-7./[4]Raj GV, et al. Guanosine phosphate binding protein coupled receptors in prostate cancer: a review. J Urol. 2002 Mar;167(3):1458-63.
CAS Number: 7415-69-2
Molecular Weight: 487.16
Compound Purity: 99.0
Research Area: Inflammation/Immunology; Neurological Disease; Cancer
Solubility: H2O : 62.5 mg/mL (ultrasonic)
Target: Endogenous Metabolite;Potassium Channel
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