Formal Name: guanosine, 5'-[hydrogen P-(phosphonomethyl)phosphonate], trisodium salt
Purity: ≥95%
Formula Markup: C11H14N5O10P2 / 3Na
Formula Weight: 507.173392
Notes: Guanosine 5'-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73 (Ki = 410 nM for the recombinant human enzyme).{65642} It also induces tubulin polymerization when used at a concentration of 1 mM.{65643} Guanosine 5'-methylenediphosphate has been used as a precursor in the synthesis of hydrolysis-resistant affinity resins for the purification of mRNA cap-binding proteins such as eukaryotic translation initiation factor 4E (eIF4E).{65644}