Guvacine hydrochloride, CAS 6027-91-4

Guvacine hydrochloride, CAS 6027-91-4
SKU
MEXHY-100809-100
Packaging Unit
100 mg
Manufacturer
MedChemExpress

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Product Description: Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

Applications: Neuroscience-Neuromodulation

Formula: C6H10ClNO2

References: [1]Borden LA, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24./[2]Krogsgaard-Larsen P, et al. Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J Neurochem. 1978 Jun;30(6):1377-82./[3]Lodge D, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.

CAS Number: 6027-91-4

Molecular Weight: 163.60

Compound Purity: 99.73

Research Area: Neurological Disease

Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 41.67 mg/mL (ultrasonic)

Target: GABA Receptor
More Information
SKU MEXHY-100809-100
Manufacturer MedChemExpress
Manufacturer SKU HY-100809-100
Package Unit 100 mg
Quantity Unit STK
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