Product Description: Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
Applications: Neuroscience-Neuromodulation
Formula: C6H10ClNO2
References: [1]Borden LA, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24./[2]Krogsgaard-Larsen P, et al. Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J Neurochem. 1978 Jun;30(6):1377-82./[3]Lodge D, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.
CAS Number: 6027-91-4
Molecular Weight: 163.60
Compound Purity: 99.73
Research Area: Neurological Disease
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 41.67 mg/mL (ultrasonic)
Target: GABA Receptor
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