GW 5074, CAS 220904-83-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one

Purity: ≥98% (mixture of cis and trans)

Formula Markup: C15H8Br2INO2

Formula Weight: 520.9

CAS Number: 220904-83-6

Notes: Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway.{14539,15155} This pathway mediates basic cellular functions, including proliferation, differentiation, and survival.{14539} GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM).{24584} It blocks phosphorylation of ERK1/2 by 90% in cells stimulated with epidermal growth factor when given at 5 µM.{24584} GW 5074 shows more than 100-fold selectivity for Raf-1 versus several related kinases.{24584}

• SKU: CAY10010368-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10010368-1
• Package Unit: 1 mg
• Quantity Unit: STK