Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (p-methoxyphenyl)morpholino-phosphinodithioic acid
Purity: ≥95%
Formula Markup: C11H16NO2PS2 / C4H10NO
Formula Weight: 377.5
CAS Number: 106740-09-4
Notes: Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor.{17169} When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.{17169} Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.{17285}
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