Product Description: H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
Applications: Neuroscience-Neuromodulation
Formula: C16H23Cl2N3O2S
Citations: Research Square Preprint. 2021 Jun./Acta Neuropathol Commun. 2024 Sep 14;12(1):150.
References: [1]Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12./[2]Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81(1):9-16./[3]Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169(2):855-62.
CAS Number: 871543-07-6
Molecular Weight: 392.34
Compound Purity: 99.09
Research Area: Neurological Disease
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 35.71 mg/mL (ultrasonic)
Target: ROCK
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