Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-methyl-1-piperazinecarboxylic acid, (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(1E,3E,5R)-1-methyl-5-(2-pyridinyl)-1,3-hexadien-1-yl]-12-oxooxacyclododec-4-en-6-yl ester
Purity: ≥98%
Formula Markup: C31H45N3O6
Formula Weight: 555.70562
CAS Number: 1825302-42-8
Notes: An inhibitor of the SF3B complex; binds to SF3B complexes containing wild-type SF3B (IC50 = 1.4 nM) or various SF3B mutations (IC50s = 0.3-1.8 nM); inhibits SF3B1-induced splicing of canonical and aberrant pre-mRNA junctions in HEK293T nuclear extracts overexpressing SF3B1K700E; selectively inhibits the growth of, and induces apoptosis in, Panc 05.04 pancreatic cancer cells expressing mutant SF3B over Panc 10.05, HAPF-II, and CFPAC-1 pancreatic cancer cells expressing wild-type SF3B in a concentration-dependent manner; reduces tumor growth in a K562 mouse xenograft model using K562 cells expressing wild-type SF3B1 at 8 mg/kg and K562 cells expressing SF3B1K700E at 2, 4, or 8 mg/kg
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