HaloPROTAC-E, CAS 2365478-58-4

Product Description: HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.

Applications: COVID-19-immunoregulation

Formula: C39H56ClN5O8S

References: [1]Tovell H, Testa A, Maniaci C, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019;14(5):882-892.

CAS Number: 2365478-58-4

Molecular Weight: 790.41

Compound Purity: 99.62

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Autophagy;PROTACs;SGK

• SKU: MEXHY-145752-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-145752-1
• Package Unit: 1 mg
• Quantity Unit: STK