HAMNO, CAS 138736-73-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-[[(2-hydroxyphenyl)amino]methylene]-2(1H)-naphthalenone

Purity: ≥95%

Formula Markup: C17H13NO2

Formula Weight: 263.29066

CAS Number: 138736-73-9

Notes: HAMNO is a small molecule inhibitor of replication protein A (RPA).{45417} It selectively binds to and inhibits DNA binding domain F (DBD-F) on RPA70 when used at concentrations up to 100 µM. HAMNO inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells when used at concentrations of 10 and 20 µM. HAMNO (1 mg/kg), in combination with etoposide (Item No. 12092), reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models.

• SKU: CAY27631-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27631-5
• Package Unit: 5 mg
• Quantity Unit: STK