HC-067047, CAS 883031-03-6

Product Description: HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C26H28F3N3O2

References: [1]Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9./[2]Xing Y, et al. Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. Yonsei Med J. 2018 Nov;59(9):1131-1137.

CAS Number: 883031-03-6

Molecular Weight: 471.51

Compound Purity: 99.89

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: TRP Channel

• SKU: MEXHY-100208-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100208-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK