Target Synonym: HDAC4;AHO3;BDMR;HA6116;HD4;HDAC-4;HDAC-A;HDACA
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human HDAC4
Dilution: WB 1:500-1:2000
Calculated MW: 106kDa/119kDa
Observed MW: 130kDa
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