Heclin, CAS 890605-54-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Purity: ≥98%

Formula Markup: C17H17NO3

Formula Weight: 283.32182

CAS Number: 890605-54-6

Notes: Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively).{43931} It inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 μM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2. Heclin is cytotoxic to HEK293 cells (IC50 = 45 μM).

• SKU: CAY26139-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26139-5
• Package Unit: 5 mg
• Quantity Unit: STK