Heptamidine (dimethanesulfonate), CAS 161374-55-6

Product Description: Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].

Applications: COVID-19-immunoregulation

Formula: C23H36N4O8S2

References: [1]McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett. 2012 Dec 13;3(12):975-979. Epub 2012 Sep 25./[2]Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol. 2013 Nov 15;8(11):2528-37.

CAS Number: 161374-55-6

Molecular Weight: 560.68

Compound Purity: 99.82

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 62.5 mg/mL (ultrasonic)

Target: Others

• SKU: MEXHY-16918A-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-16918A-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK