Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-(4-methoxy-13C-d3)phenyl)-4H-1-benzopyran-4-one
Purity: ≥99% deuterated forms (d1-d3).
Formula Markup: C15[13C]H11D3O6
Formula Weight: 306.3
CAS Number: 2750534-85-9
Notes: Hesperetin-13C-d3 is intended for use as an internal standard for the quantification of hesperetin (Item No. 10006084) by GC- or LC-MS. Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.{10842,12523,53902,53903,53904} It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 µM.{10842} Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml).{12523} It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells.{53902} Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice.{12523} It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis.{53903} Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.{53904}
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