HhAntag, CAS 496794-70-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxy-benzamide

Purity: ≥95%

Formula Markup: C24H23ClN4O3

Formula Weight: 450.91728

CAS Number: 496794-70-8

Notes: HhAntag is an inhibitor of the Sonic Hedgehog (Shh) pathway (EC50 = 0.4 μM for Shh signaling in a reporter assay).{47559} It inhibits proliferation of GNP cells when used at concentrations ranging from 0.1 nM to 25 μM. In vivo, HhAntag (20 or 100 mg/kg) suppresses Gli1 mRNA levels, a target of Shh signaling, and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma. HhAntag also blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells.{47560}

• SKU: CAY28296-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28296-10
• Package Unit: 10 mg
• Quantity Unit: STK