HJC0197, CAS 1383539-73-8

Product Description: HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C19H21N3OS

References: [1]Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

CAS Number: 1383539-73-8

Molecular Weight: 339.45

Compound Purity: 99.58

Research Area: Cancer; Metabolic Disease; Cardiovascular Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : ≥ 1.67 mg/mL

Target: Ras

• SKU: MEXHY-117958-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-117958-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK