HJC0350, CAS 885434-70-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole

Purity: ≥98%

Formula Markup: C15H19NO2S

Formula Weight: 277.4

CAS Number: 885434-70-8

Notes: HJC0350 is a selective inhibitor of exchange protein directly activated by cAMP 2 (Epac2) with an IC50 value of 300 nM for competition with 8-NBD-cAMP binding.{39180} It inhibits Epac2 guanine nucleotide exchange activity but does not inhibit Epac1-mediated Rap1-GDP exchange or cAMP-mediated protein kinase A (PKA) activation in vitro, indicating it is selective for Epac2 at a concentration of 25 μM. HJC0350 also blocks stimulation of Epac2, but not Epac1, by 007-AM in HEK293 cells.

• SKU: CAY22949-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22949-5
• Package Unit: 5 mg
• Quantity Unit: STK