Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 9-ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C23H24N2O / HCl
Formula Weight: 380.9
CAS Number: 1158279-20-9
Notes: HLCL-61 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) that inhibits the growth of multiple acute myeloid leukemia (AML) cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively).{38426} It is selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay. HLCL-61 induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner. It also increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter.
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