Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-ethyl-5,6-dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine
Purity: ≥98%
Formula Markup: C17H17NO2
Formula Weight: 267.3
CAS Number: 854847-61-3
Notes: Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{14336,13185,17947} HLY78 is a positive modulator of the Wnt/β-catenin pathway, as it augments Wnt-mediated signaling in cells at concentrations of 5 to 20 µM.{30791} It has no significant effect alone, and it does not affect LiCl-stimulated β-catenin signaling. A biotinylated form of HLY78 binds Axin at its DIX domain, which is thought to potentiate Axin-LRP6 association.{30791} HLY78 activates Wnt signaling in vivo, altering Wnt-dependent gene expression and embryonic development in zebrafish.{30791}
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