HPOB, CAS 1429651-50-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide

Purity: ≥95%

Formula Markup: C17H18N2O4

Formula Weight: 314.3

CAS Number: 1429651-50-2

Notes: HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).{28379} It is at least 30-fold less effective against other HDACs.{28379} Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.{28379} HPOB reduces the growth, but not the viability, of normal and transformed cells.{28379} It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.{28379} HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft.{28379}

• SKU: CAY15066-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15066-10
• Package Unit: 10 mg
• Quantity Unit: STK