hSMG-1 Inhibitor 11j, CAS 1402452-15-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C27H28ClN7O3S

Formula Weight: 566.1

CAS Number: 1402452-15-6

Notes: An SMG1 inhibitor (IC50 = 0.11 nM); selective for SMG1 over mTOR, Cdk1, Cdk2, PI3Kα, and PI3Kγ (IC50s = 0.05, 32, 7.1, 0.092 and 0.06 µM, respectively) and a panel of 25 additional kinases (IC50s = >10 µM) but does inhibit GSKα and GSKβ (IC50s = 0.26 and 0.33 µM, respectively); decreases the phosphorylation of the SMG1 substrate UPF1 in MDA-MB-361 cells from 0.3-3 µM; inhibits the proliferation of MDA-MB-468 cells (IC50 = 0.075 µM)

• SKU: CAY41724-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41724-10
• Package Unit: 10 mg
• Quantity Unit: STK