Product Description: hSTING activator-1 (Compound 68) is a STING agonist. hSTING activator-1 can effectively activate multiple human STING variants (R232, H232, HAQ) with EC50 values of 56 nM, 89 nM and 51 nM, respectively. hSTING activator-1 activates the type I interferon pathway by directly binding to STING protein and stabilizing its conformation, promoting downstream IRF3 phosphorylation and cytokine release. hSTING activator-1 inhibits fibrosarcoma tumor growth and has potential in cancer research[1].
Applications: COVID-19-immunoregulation
Formula: C26H19FN4O2S
References: [1]Basu S, et al. Synthesis and structure-activity evaluation of a series of novel tricyclic STING activators. Eur J Med Chem. 2025 Jun 5;290:117577.
Molecular Weight: 470.52
Research Area: Cancer; Inflammation/Immunology
Target: IFNAR;Interleukin Related;STING
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