Shelf life (days): 730.0
Formulation: A 25 µg/ml solution in acetonitrile
Formal Name: (2S,2'R,3'R,4'S,5'S,5a'R,7'S,9a'R)-5a'-((acetoxy-13C2)methyl-13C)-3',4'-dihydroxy-5',8'-di(methyl-13C)-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-7'-yl-2,2',3,3',4',5',5a',6',7',8',9',9a'-13C12 3-(methyl-13C)butanoate-1,2,3,4-13C4
Purity: ≥98%
Formula Markup: [13C]22H32O8
Formula Weight: 446.3
CAS Number: 1486469-92-4
Notes: HT-2 toxin-13C22 is intended for use as an internal standard for the quantification of HT-2 toxin (Item No. 20431) by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin (Item No. 11444).{53282,31995} Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.{31995} HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50 values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells with an IC50 value of 56.4 ng/ml.{53282} It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.{59456} HT-2 toxin has been found in cereal grains and food products.{59457,59458}
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